Age-Dependency of Neurite Outgrowth in Postnatal Mouse Cochlear Spiral Ganglion Explants
نویسندگان
چکیده
منابع مشابه
Automated analysis of neurite outgrowth in mouse retinal explants.
Despite intensive research efforts over the past years, regeneration of injured axons in the central nervous system remains elusive. In the quest for neurostimulatory agents that promote regeneration, well-defined models and analysis methods are required. Tissue explant cultures closely resemble the in vivo situation, making them ideal to study the effect of compounds on the neuro-glial network...
متن کاملFunctional Pattern of Increasing Concentrations of Brain-Derived Neurotrophic Factor in Spiral Ganglion: Implications for Research on Cochlear Implants
BACKGROUND As previously various studies have suggested application of brain-derived neurotrophic factor (BDNF) may be considered as a promising future therapy for hearing deficits, in particular for the improvement of cochlear neurone loss during cochlear implantation. AIM The present study's aim was to establish the upper threshold of the concentration of BDNF in Naval Medical Research Inst...
متن کاملPromotion of neurite outgrowth and axon guidance in spiral ganglion cells by netrin-1.
OBJECTIVE To identify the expression of netrin-1, a diffusible chemoattractive molecule, and its receptor, deleted in colorectal carcinoma (DCC), in the developmentally mature inner ear, and to determine its effects on axon length and guidance in cultured auditory neurons. DESIGN Messenger RNA (mRNA) and protein expression of netrin-1 and DCC were identified in the organ of Corti and spiral g...
متن کاملAnalyzing neurite outgrowth from explants by fitting ellipses.
The establishment of appropriate connectivity in the developing nervous system depends on many molecular guidance cues. A key method for studying the response of nerve fibers to such guidance cues is to culture explants of neural tissue in three-dimensional collagen gels. However, most previous analyses of the neurite outgrowth patterns from these explants have been very simple, often measuring...
متن کاملHydrocortisone stimulates neurite outgrowth from mouse retinal explants by modulating macroglial activity.
PURPOSE There is mounting evidence that retinal ganglion cells (RGCs) require a complex milieu of trophic factors to enhance cell survival and axon regeneration after optic nerve injury. The authors' goal was to examine the contribution of components of a combination of hormones, growth factors, steroids, and small molecules to creating a regenerative environment and to determine if any of thes...
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ژورنال
عنوان ژورنال: Brain Sciences
سال: 2020
ISSN: 2076-3425
DOI: 10.3390/brainsci10090580